Linear polyketides produced by co-culture of Penicillium crustosum and Penicillium fellutanum.

ABSTRACT: Two new polyketides, penifellutins A (1) and B (2), possessing a 22 carbon linear skeleton, were isolated from a co-culture of the deep-sea-derived fungi Penicillium crustosum PRB-2 and Penicillium fellutanum HDN14-323. Meanwhile, two esterification products of 1, penifellutins C (3) and D (4), were obtained because compound 1 could be esterified spontaneously when stored in methanol. Their configurations were difficult to determine because of chiral central crowdedness, structural flexibility and instability. As such, we solved this issue by comprehensively using Mo₂(OAc)₄-based CD experiments, density functional theory calculation of ¹³C NMR, DP4 + probability analysis and many chemical reactions, in

SUBMITTER: Yu G 

PROVIDER: S-EPMC10077197 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature