The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).

ABSTRACT: Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure-activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review

SUBMITTER: Hai Y 

PROVIDER: S-EPMC10077240 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature