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Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures.

ABSTRACT: Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019.

SUBMITTER: Meng ZH

PROVIDER: S-EPMC10077242 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures.

Meng Zhi-Hui ZH Sun Tian-Tian TT Zhao Guo-Zheng GZ Yue Yu-Fei YF Chang Qing-Hua QH Zhu Hua-Jie HJ Cao Fei F

Marine life science & technology 20201124 1

Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 ...[more]

PMID: 37073395

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