Co-culture: stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms.

ABSTRACT: Microbial secondary metabolites have long been considered as potential sources of lead compounds for medicinal use due to their rich chemical diversity and extensive biological activities. However, many biosynthetic gene clusters remain silent under traditional laboratory culture conditions, resulting in repeated isolation of a large number of known compounds. The co-culture strategy simulates the complex ecological environment of microbial life by using an ecology-driven method to activate silent gene clusters of microorganisms and tap their metabolic potential to obtain novel bioactive secondary metabolites. In this review, representative studies from 2017 to 2020 on the discovery of novel bioactive natural products from co-cultured microorganisms are summarized. A series of natural prod

SUBMITTER: Peng XY 

PROVIDER: S-EPMC10077301 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature