An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants.

ABSTRACT: As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be important globally. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of novel variants has created a moving target for our immune systems and public health alike. The temporal aspects of COVID-19 immunity, particularly from repeated vaccination and infection, are less well understood than short-term vaccine efficacy. In this study, we explored the effect of combined vaccination and infection, also known as hybrid immunity, and the timing thereof on the quality and quantity of antibodies elicited in a cohort of 96 health care workers. We found robust neutralizing antibody responses among those with hybrid immunity; these hybrid immune responses neutralized

SUBMITTER: Bates TA 

PROVIDER: S-EPMC10077480 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature