Construction and evaluation of Alzheimer's disease diagnostic prediction model based on genes involved in mitophagy.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a common neurodegenerative disease. The concealment of the disease is the difficulty of its prevention and treatment. Previous studies have shown that mitophagy is crucial to the development of AD. However, there is a lack of research on the identification and clinical significance of mitophagy-related genes in AD. Therefore, the purpose of this study was to identify the mitophagy-related genes with the diagnostic potential for AD and establish a diagnostic model for AD.

Methods

Firstly, we download the AD gene expression profile from Gene Expression Omnibus (GEO). Limma, PPI, functional enrichment analysis and WGCNA were used to screen the differential expression of mitophagy-related AD gene. Then, machine learning methods (random fo

SUBMITTER: Pei Y 

PROVIDER: S-EPMC10077494 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature