Impact of Mesoporous Silica Functionalization Fine-Tuning on Antibiotic Uptake/Delivery and Bactericidal Activity.

ABSTRACT: The mesoporous SBA-15 material was surface-functionalized with amino and carboxylic acid groups and used as a platform to investigate the interaction of these chemical groups with tetracycline, kanamycin, and ampicillin antibiotics. The interactions between the antibiotic and the functionalized surfaces were characterized using two-dimensional ¹H-¹³C HETCOR CP MAS and FTIR spectroscopy and indicated that -COO^- NH₃ ⁺ bondings had been formed between chemical groups on the silica surface and drug molecules. The surface modification resulted in higher kanamycin and ampicillin loadings and a slow-release rate, and all synthesized systems showed antibacterial activity against susceptible Escherichia coli bacteria. Almost total death

SUBMITTER: Bouchmella K 

PROVIDER: S-EPMC10077561 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature