Determinants of Superselectivity─Practical Concepts for Application in Biology and Medicine.

ABSTRACT: Multivalent interactions are common in biological systems and are also widely deployed for targeting applications in biomedicine. A unique feature of multivalent binding is "superselectivity". Superselectivity refers to the sharp discrimination of surfaces (e.g., on cells or cell compartments) by their comparative surface densities of a given receptor. This feature is different from the conventional "type" selectivity, which discriminates surfaces by their distinct receptor types. In a broader definition, a probe is superselective if it converts a gradual change in any one interaction parameter into a sharp on/off dependency in probe binding.This Account describes our systematic experimental and theoretical efforts over the past decade to analyze the determinants of superselective binding.

SUBMITTER: Dubacheva GV 

PROVIDER: S-EPMC10077582 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature