Demographic Determinants of Residue Profiles of Fungicidal Compounds in Common Voles (Microtus arvalis) under Semi-Natural and Natural Conditions.

ABSTRACT: Environmental risks from plant protection products (PPPs) need to be assessed to ensure safe use. The risk assessments are generally carried out using the common vole as a focal species with conservative theoretical estimates of external exposure. These are then compared to dose-related toxicity endpoints established in toxicity studies, often with laboratory species. The aim of the present study was to determine the actual internal dosimetry of PPPs' active ingredients (AIs) in a population of common voles to provide the basis for informed higher tier risk assessment. As a proof of concept, two fungicidal AIs (fludioxonil and cyprodinil) were investigated using a range of application methodologies. Individuals were treated using oral gavage application (AI dose: 100/200 mg/kg) and fed tre

SUBMITTER: Imholt C 

PROVIDER: S-EPMC10077593 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature