Prognostic values of tissue-resident CD8⁺T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

Tissue-resident CD8⁺T cells (CD103⁺CD8⁺T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote the proliferation and effector function of tissue-resident CD103⁺CD8⁺T cells. As of now, the immunolocalization and the prognostic values of tissue-resident CD8⁺T cells in human hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) still remain to be illustrated.

Methods

In our present study, we used the tissue microarrays of HCC and ICC, the multicolor immunohistochemistry (mIHC), and imaging analysis to characterize the tissue-resident CD8⁺T cells in HCC and ICC tissues. The pr

SUBMITTER: Chen L 

PROVIDER: S-EPMC10077621 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature