The role of EMILIN-1 in the osteo/odontogenic differentiation of dental pulp stem cells.

ABSTRACT:

Background

Human dental pulp stem cells (hDPSCs) may be the best choice for self-repair and regeneration of teeth and maxillofacial bone tissue due to their homogeneous tissue origin, high proliferation and differentiation rates, and no obvious ethical restrictions. Recently, several studies have shown that extracellular matrix (ECM) proteins can effectively regulate the proliferation and differentiation fate of mesenchymal stem cells (MSCs). However, the role of elastin microfibril interface-located protein-1 (EMILIN-1), a new ECM glycoprotein, in osteo/odontogenic differentiation of hDPSCs has not been reported. The aim of this study was to explore the effect of EMILIN-1 during osteo/odontogenic differentiation of hDPSCs.

Methods

hDPSCs were cultured in osteo/odontogenic i

SUBMITTER: Deng P 

PROVIDER: S-EPMC10077624 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature