RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling.

ABSTRACT:

Background

The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis. The RhoA protein of GTPase plays a regulatory role in cytoskeletal components and contributes to osteoclast adhesion, podosome positioning, and differentiation. Although osteoclast investigations have traditionally been performed by in vitro analysis, however, the results have been inconsistent, and the significance of RhoA in bone physiology and pathology is still unknown.

Methods

We generated RhoA knockout mice by specifically deleting RhoA in the osteoclast lineage to understand more about RhoA's involvement in bone remodeling. The function of RhoA in osteoclast differentiation and bo

SUBMITTER: Wang J 

PROVIDER: S-EPMC10077675 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature