Comparative genomics analyses reveal sequence determinants underlying interspecies variations in injury-responsive enhancers.

ABSTRACT:

Background

Injury induces profound transcriptional remodeling events, which could lead to only wound healing, partial tissue repair, or perfect regeneration in different species. Injury-responsive enhancers (IREs) are cis-regulatory elements activated in response to injury signals, and have been demonstrated to promote tissue regeneration in some organisms such as zebrafish and flies. However, the functional significances of IREs in mammals remain elusive. Moreover, whether the transcriptional responses elicited by IREs upon injury are conserved or specialized in different species, and what sequence features may underlie the functional variations of IREs have not been elucidated.

Results

We identified a set of IREs that are activated in both regenerative and non-regenerative

SUBMITTER: Ji L 

PROVIDER: S-EPMC10077677 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature