Ultra-sensitive specific detection of nucleic acids in pathogenic infections by Ta₂C-MXene sensitization-based ultrafine plasmon spectroscopy combs.

ABSTRACT: Accurate and rapid population-scale screening techniques based on SARS-CoV-2 RNA are essential in preventing and controlling the COVID-19 epidemic. However, the sensitivity and specificity of the assay signal are challenged by the problems of target dilution and sample contamination inherent in high-volume pooled testing. Here, we reported a collaborative system of high-loaded hybrid probes targeting N and OFR1a coupling with the novel Ta₂C-M/Au/TFBG biosensor, providing high-intensity vector signals for detecting SARS-CoV-2. The method relies on a segmental modification approach to saturable modify multiple activation sites of SARS-CoV-2 on the high-performance Ta₂C-M surface. The coupling of multi-site synergy with composite excited TFBG results in excellent signal

SUBMITTER: Yang W 

PROVIDER: S-EPMC10077810 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature