Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy.

ABSTRACT:

Objectives

To examine associations of pituitary-ovarian hormone levels with cognition before and after different formulations of hormone therapy (HT) or placebo independent of treatment group.

Methods

Recently menopausal, healthy women were randomized to 0.45 mg/day oral conjugated equine estrogens (o-CEE, n = 109), 50 μg/day transdermal 17β (tE2, n = 107) or placebo pills and patches (n = 146); women on active treatment received oral 200 mg/day micronized progesterone for 12 days per month. Levels of estrone, 17β-estradiol, follicle stimulating hormone, luteinizing hormone, androstenedione, and testosterone were determined prior to and after 48 months of study participation. Neuropsychological testing was administered at baseline, and months 18, 36 and 48. Latent growth cur

SUBMITTER: Kling JM 

PROVIDER: S-EPMC10077876 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature