Nicotine Enhances Intravenous Self-administration of Cannabinoids in Adult Rats.

ABSTRACT:

Introduction

Nicotine and cannabis are commonly used together, yet few studies have investigated the effects of concurrent administration. Nicotine exhibits reinforcement enhancing effects by promoting the reinforcing properties of stimuli including other drugs. As many studies of this effect used non-contingent nicotine, we implemented a dual-self-administration model where rats have simultaneous access to two drugs and choose which to self-administer throughout a session. Here, we investigated the effect of self-administered or non-contingently delivered nicotine on cannabinoid self-administration.

Methods

Adult male rats were allowed to self-administer the synthetic cannabinoid WIN 55,212-2 (WIN) intravenously, with or without subcutaneous nicotine injections before each

SUBMITTER: Stringfield SJ 

PROVIDER: S-EPMC10077937 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature