Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice.

ABSTRACT: Mechanical unloading causes rapid loss of bone structure and strength, which gradually recovers after resuming normal loading. However, it is not well established how this adaptation to unloading and reloading changes with age. Clinically, elderly patients are more prone to musculoskeletal injury and longer periods of bedrest, therefore it is important to understand how periods of disuse will affect overall skeletal health of aged subjects. Bone also undergoes an age-related decrease in osteocyte density, which may impair mechanoresponsiveness. In this study, we examined bone adaptation during unloading and subsequent reloading in mice. Specifically, we examined the differences in bone adaptation between young mice (3-month-old), old mice (18-month-old), and transgenic mice that exhibit di

SUBMITTER: Cunningham HC 

PROVIDER: S-EPMC10077944 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature