The relationship between epigenetic age and the hallmarks of aging in human cells.

ABSTRACT: Epigenetic clocks are mathematically derived age estimators that are based on combinations of methylation values that change with age at specific CpGs in the genome. These clocks are widely used to measure the age of tissues and cells^1,2. The discrepancy between epigenetic age (EpiAge), as estimated by these clocks, and chronological age is referred to as EpiAge acceleration. Epidemiological studies have linked EpiAge acceleration to a wide variety of pathologies, health states, lifestyle, mental state and environmental factors², indicating that epigenetic clocks tap into critical biological processes that are involved in aging. Despite the importance of this inference, the mechanisms underpinning these clocks remained largely uncharacterized and unelucidated. Here, u

SUBMITTER: Kabacik S 

PROVIDER: S-EPMC10077971 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature