Glomerular macrophage index (GMI) in kidney transplant biopsies is associated with graft outcome.

ABSTRACT:

Background

Macrophages in renal transplants have been shown to participate in antibody-mediated rejection and are associated with impaired renal function. We calculated the glomerular macrophage index (GMI) in a large transplant biopsy cohort, studied its quantity in different diagnostic groups, to clarify its possible impact on graft survival.

Methods

GMI, defined as the mean number of macrophages in 10 glomeruli, was prospectively quantified in 1440 renal transplant biopsies over a 10-year period. The main histopathological diagnoses were grouped into eight disease entities, and GMI was compared to normal transplant biopsies as the reference group. The impact of GMI on graft survival was analyzed.

Results

GMI was highest in chronic (mean 9.4) and active (9.7) antibo

SUBMITTER: Molne J 

PROVIDER: S-EPMC10077994 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature