Recovery and sequelae in 523 adults and children with tick-borne encephalitis in Germany.

ABSTRACT:

Purpose

Despite being vaccine-preventable, tick-borne encephalitis (TBE) continues to cause considerable morbidity in Germany. Limited insight into potentially debilitating consequences of TBE may partially underly low (~ 20%) TBE vaccine uptake. We aimed to systematically assess TBE sequelae and other consequences.

Methods

Routinely notified TBE patients from 2018 to 2020 from Southern Germany were invited to telephone interviews acutely and again after 18 months. Duration of acute symptoms was prospectively assessed. Recovery was defined as score 0 on the modified RANKIN scale. Determinants of time to recovery were analysed with cox regression, adjusted for covariates identified using directed acyclic graphs, yielding hazard ratios (HR) and 95% confidence intervals (CI).

SUBMITTER: Nygren TM 

PROVIDER: S-EPMC10078068 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature