Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors.

ABSTRACT:

Background

The impact of donor age on the immune reconstitution of patients with hematological malignancies who underwent hematopoietic cell transplantation (HCT) is unclear.

Method

We retrospectively compared the outcomes of 381 patients who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from 308 donors under 50 years of age and 73 donors over 50 years of age. IVIG was regularly supplemented for patients in the first 3 months post-HCT.

Results

The counts of CD8+CD45RA+ naïve T cells were significantly lower in patients of the older donor group than in the younger donor group in the first year after PBSCT (190.6 cells/μl vs. 239.6 cells/μl, p = .018). Patients in the older donor group had significantly fewer CD19+ B cells on day +270 (123.4 ce

SUBMITTER: Jiang P 

PROVIDER: S-EPMC10078254 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature