Defining the separation landscape of topological domains for decoding consensus domain organization of the 3D genome.

ABSTRACT: Topologically associating domains (TADs) have emerged as basic structural and functional units of genome organization and have been determined by many computational methods from Hi-C contact maps. However, the TADs obtained by different methods vary greatly, which makes the accurate determination of TADs a challenging issue and hinders subsequent biological analyses about their organization and functions. Obvious inconsistencies among the TADs identified by different methods indeed make the statistical and biological properties of TADs overly depend on the chosen method rather than on the data. To this end, we use the consensus structural information captured by these methods to define the TAD separation landscape for decoding the consensus domain organization of the 3D genome. We show tha

SUBMITTER: Dang D 

PROVIDER: S-EPMC10078287 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature