Torque teno virus load as marker of rejection and infection in solid organ transplantation - A systematic review and meta-analysis.

ABSTRACT: Balancing immunosuppression to prevent rejection in solid organ transplant (SOT) recipients remains challenging. Torque teno virus (TTV), a commensal non-pathogenic virus, has been proposed as marker of functional immunity: higher loads correspond to over-immunosuppression, and lower loads to under-immunosuppression. This review offers an overview of the current evidence of the association between TTV-load and infection and rejection after SOT. A systematic literature search strategy, deposited in the PROSPERO registry, resulted in 548 records. After screening, 23 original and peer-reviewed articles were assessed investigating the association between TTV-load, infection and/or rejection in SOT. The Quality in Prognostic Studies (QUIPS)-tool was used to assess the risk of bias. Meta-analysi

SUBMITTER: van Rijn AL 

PROVIDER: S-EPMC10078304 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature