Long Term Weight Cycling Affects Fecal Microbiota of Mice.

ABSTRACT:

Scope

Fighting obesity and associated comorbidities through dieting is not always sustained and results in a subsequent weight gain, a phenomenon referred to as weight cycling. Diet is among the most important factors in modifying the composition of gut microbiota. The objective of this work is to determine whether weight cycling affects the composition and the predicted function of mouse fecal bacteria on a long-term basis.

Methods and results

Mice fed for 40 weeks with either high fat (HF), low fat (LF), or cycled diets (starting and ending by one of the two diets, and the reverse) exhibit a bacterial profile specific to each of the four groups. A higher proportion of Firmicutes and Bacteroidota phyla are observed in mice on Hf and LF diet, respectively. The proportion of

SUBMITTER: Humblot C 

PROVIDER: S-EPMC10078315 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature