Comparison of laser speckle contrast imaging with laser Doppler perfusion imaging for tissue perfusion measurement.

ABSTRACT:

Objective

Laser-based tissue perfusion monitoring techniques have been increasingly used in animal and human research to assess blood flow. However, these techniques use arbitrary units, and knowledge about their comparability is scarce. This study aimed to model the relationship between laser speckle contrast imaging (LSCI) and laser Doppler perfusion imaging (LDPI), for measuring tissue perfusion over a wide range of blood flux values.

Methods

Fifteen healthy volunteers (53% female, median age 29 [IQR 22-40] years) were enrolled in this study. We performed iontophoresis with sodium nitroprusside on the forearm to induce regional vasodilation to increase skin blood flux. Besides, a stepwise vascular occlusion was applied on the contralateral upper arm to reduce blood flux.

SUBMITTER: Guven G 

PROVIDER: S-EPMC10078364 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature