Placebo response in pharmacological trials in patients with functional dyspepsia-A systematic review and meta-analysis.

ABSTRACT:

Background

Pharmacological trials in functional dyspepsia (FD) are associated with high placebo response rates. We aimed to identify the magnitude and contributing factors to the placebo response.

Methods

We conducted a systematic review and meta-analysis including randomized controlled trials (RCTs) with a dichotomous outcome in adult patients with FD that compared an active pharmacotherapeutic treatment with placebo. Our main outcome was identification of the magnitude of the pooled placebo response rate for the following endpoints: symptom responder, symptom-free responder, adequate relief responder, and combined endpoint responder (i.e., the primary endpoint of each specific trial regarding treatment response). Several putative moderators (i.e., patient, disease, and tri

SUBMITTER: Bosman M 

PROVIDER: S-EPMC10078497 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature