Diffusion MRI with pulsed and free gradient waveforms: Effects of restricted diffusion and exchange.

ABSTRACT: Monitoring time dependence with diffusion MRI yields observables sensitive to compartment sizes (restricted diffusion) and membrane permeability (water exchange). However, restricted diffusion and exchange have opposite effects on the diffusion-weighted signal, which can lead to errors in parameter estimates. In this work, we propose a signal representation that incorporates the effects of both restricted diffusion and exchange up to second order in b-value and is compatible with gradient waveforms of arbitrary shape. The representation features mappings from a gradient waveform to two scalars that separately control the sensitivity to restriction and exchange. We demonstrate that these scalars span a two-dimensional space that can be used to choose waveforms that selectively probe restric

SUBMITTER: Chakwizira A 

PROVIDER: S-EPMC10078514 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature