Conservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi.

ABSTRACT:

Background

Streptococcus equi subspecies equi (S equi) is the cause of Strangles, one of the most prevalent diseases of horses worldwide. Variation within the immunodominant SeM protein has been documented, but a new eight-component fusion protein vaccine, Strangvac, does not contain live S equi or SeM and conservation of the antigens it contains have not been reported.

Objective

To define the diversity of the eight Strangvac antigens across a diverse S equi population.

Study design

Genomic description.

Methods

Antigen sequences from the genomes of 759 S equi isolates from 19 countries, recovered between 1955 and 2018, were analysed. Predicted amino acid sequences in the antigen fragments of SEQ0256(Eq5), SEQ0402(Eq8), SEQ0721(EAG), SEQ0855(SclF), SEQ0935(CNE),

SUBMITTER: Frosth S 

PROVIDER: S-EPMC10078666 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature