Association of life-course traumatic brain injury with dementia risk: A nationwide twin study.

ABSTRACT:

Introduction

The impact of life-course traumatic brain injury (TBI) on dementia is unclear.

Methods

Within the Swedish Twin Registry (STR), 35,312 dementia-free twins were followed for up to 18 years. TBI history was identified via medical records. Data were analyzed using generalized estimating equation (GEE) and conditional logistic regression.

Results

In multi-adjusted GEE models, the odds ratio (OR, 95% confidence interval [CI]) of dementia was 1.27 (1.03-1.57) for TBI at any age, 1.55 (1.04-2.31) for TBI at 50 to 59 years, and 1.67 (1.12-2.49) for TBI at 60 to 69 years. Cardiometabolic diseases (CMDs) increased dementia risk associated with TBI at age 50 to 69 years. The ORs in GEE and conditional logistic regression did not differ significantly (P = .37).

Dis

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10078668 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature