Gastrointestinal symptoms in patients with isolated oligodontia and a Wnt gene mutation.

ABSTRACT:

Objective

Since Wnt signaling plays an important role in both tooth agenesis and altered intestine homeostasis, the aim was to compare gastrointestinal symptoms in patients with isolated oligodontia caused by a Wnt pathway gene mutation and controls.

Methods

A case-control study was designed to compare self-reported gastrointestinal symptoms among patients with isolated oligodontia, caused by a Wnt signaling gene mutation, and fully dentate controls. The Gastrointestinal Symptom Rating Scale (GSRS) was used to assess gastrointestinal symptoms. Prevalence and severity of gastrointestinal symptoms among patients and age- and gender-matched controls were evaluated.

Results

Twenty patients with isolated oligodontia and a pathogenic variant in the wnt pathway genes WNT10A,

SUBMITTER: Ross JN 

PROVIDER: S-EPMC10078688 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature