Regional cerebral hypometabolism on 18F-FDG PET/CT scan in delirium is independent of acute illness and dementia.

ABSTRACT:

Introduction

Delirium is associated with new onset dementia and accelerated cognitive decline; however, its pathophysiology remains unknown. Cerebral glucose metabolism previously seen in delirium may have been attributable to acute illness and/or dementia. We aimed to statistically map cerebral glucose metabolism attributable to delirium.

Methods

We assessed cerebral glucose metabolism using ¹⁸ F-fluorodeoxyglucose positron emission tomography (FDG-PET) in sick, older patients with and without delirium, all without clinical dementia (N = 20). Strict exclusion criteria were adopted to minimize the effect of established confounders on FDG-PET.

Results

Patients with delirium demonstrated hypometabolism in the bilateral thalami and right superior frontal, righ

SUBMITTER: Nitchingham A 

PROVIDER: S-EPMC10078760 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature