Genome-wide analysis reveals novel regulators of synaptic maintenance in Drosophila.

ABSTRACT: Maintaining synaptic communication is required to preserve nervous system function as an organism ages. While much work has been accomplished to understand synapse formation and development, we understand relatively little regarding maintaining synaptic integrity throughout aging. To better understand the mechanisms responsible for maintaining synaptic structure and function, we performed an unbiased forward genetic screen to identify genes required for synapse maintenance of adult Drosophila neuromuscular junctions. Using flight behavior as a screening tool, we evaluated flight ability in 198 lines from the Drosophila Genetic Reference Panel to identify single nucleotide polymorphisms (SNPs) that are associated with a progressive loss of flight ability with age. Among the many candidate g

SUBMITTER: Sidisky JM 

PROVIDER: S-EPMC10078915 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature