Subtle Pathophysiological Changes in Working Memory-Related Potentials and Intrinsic Theta Power in Community-Dwelling Older Adults With Subjective Cognitive Decline.

ABSTRACT:

Background and objectives

Individuals with subjective cognitive decline (SCD) who perform normally on objective cognitive tests may have an increased risk of pathological cognitive decline and progression to Alzheimer's disease (AD) and related dementia (ADRD). Working memory is widely regarded as an early sign of pathological cognitive decline. We tested the hypothesis that older adults with SCD already exhibit aberrant neurocognitive processing underlying working memory.

Research design and methods

Electroencephalography (EEG) was recorded during a delayed match-to-sample (DMS) task and an eyes-closed resting condition in cognitively healthy community-dwelling older adults who were assigned to the SCD or Control group.

Results

The SCD and Control groups showed compa

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC10078975 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature