Identification of male COPD patients with exertional hypoxemia who may benefit from long-term oxygen therapy.

ABSTRACT: Several studies have documented increased exercise capacity with supplemental oxygen therapy in patients with COPD and exertional hypoxemia, but a large trial failed to demonstrate a survival benefit in this population. Due to the heterogeneity observed in therapeutic responses, we sought to retrospectively evaluate survival in male COPD patients with exertional hypoxemia who had a clinically meaningful improvement in exercise capacity while using supplemental oxygen compared to their 6-minute walk test distance (6MWD) while walking on room air. We defined them as responders or non-responders based on a change in 6MWD of greater or less than 54m. We compared their clinical and physiologic characteristics, and their survival over time. From 817 COPD subjects who underwent an assessment for

SUBMITTER: Garnet BJ 

PROVIDER: S-EPMC10079074 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature