An anesthesia-centered bundle to reduce postoperative pulmonary complications: The PRIME-AIR study protocol.

ABSTRACT:

Background

Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality after open abdominal surgery. Optimized perioperative lung expansion may minimize the synergistic factors responsible for the multiple-hit perioperative pulmonary dysfunction. This ongoing study will assess whether an anesthesia-centered bundle focused on perioperative lung expansion results in decreased incidence and severity of PPCs after open abdominal surgery.

Methods

Prospective multicenter randomized controlled pragmatic trial in 750 adult patients with at least moderate risk for PPCs undergoing prolonged (≥2 hour) open abdominal surgery. Participants are randomized to receive either a bundle intervention focused on perioperative lung expansion or usual care. The bundle

SUBMITTER: Fernandez-Bustamante A 

PROVIDER: S-EPMC10079125 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature