Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity.

ABSTRACT: Habituation is a foundational learning process critical for animals to adapt their behavior to changes in their sensory environment. Although habituation is considered a simple form of learning, the identification of a multitude of molecular pathways including several neurotransmitter systems that regulate this process suggests an unexpected level of complexity. How the vertebrate brain integrates these various pathways to accomplish habituation learning, whether they act independently or intersect with one another, and whether they act via divergent or overlapping neural circuits has remained unclear. To address these questions, we combined pharmacogenetic pathway analysis with unbiased whole-brain activity mapping using the larval zebrafish. Based on our findings, we propose five distinc

SUBMITTER: Nelson JC 

PROVIDER: S-EPMC10079226 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature