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Anatomical structures, cell types and biomarkers of the Human Reference Atlas.


ABSTRACT: The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.

SUBMITTER: Borner K 

PROVIDER: S-EPMC10079270 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Anatomical structures, cell types and biomarkers of the Human Reference Atlas.

Börner Katy K   Teichmann Sarah A SA   Quardokus Ellen M EM   Gee James C JC   Browne Kristen K   Osumi-Sutherland David D   Herr Bruce W BW   Bueckle Andreas A   Paul Hrishikesh H   Haniffa Muzlifah M   Jardine Laura L   Bernard Amy A   Ding Song-Lin SL   Miller Jeremy A JA   Lin Shin S   Halushka Marc K MK   Boppana Avinash A   Longacre Teri A TA   Hickey John J   Lin Yiing Y   Valerius M Todd MT   He Yongqun Y   Pryhuber Gloria G   Sun Xin X   Jorgensen Marda M   Radtke Andrea J AJ   Wasserfall Clive C   Ginty Fiona F   Ho Jonhan J   Sunshine Joel J   Beuschel Rebecca T RT   Brusko Maigan M   Lee Sujin S   Malhotra Rajeev R   Jain Sanjay S   Weber Griffin G  

Nature cell biology 20211108 11


The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical util  ...[more]

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