Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits.

ABSTRACT:

Background

Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems.

Methods

Here, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p<0.05) in an independent cohort from FinnGen. To account for potential horizontal pl

SUBMITTER: Park JK 

PROVIDER: S-EPMC10079290 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature