Population Pharmacokinetics and Monte Carlo Simulation of Cefepime in Critically Ill Patients with Hospital-Acquired/Ventilator-Associated Pneumonia.

ABSTRACT:

Background

This study aimed to investigate the population pharmacokinetics (PK) profile and determine the optimal dosage regimen of cefepime in critically ill adult patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP).

Materials and methods

Population-PK models for cefepime were developed using a nonlinear mixed-effect modeling approach. The percentage of time within 24 h in which the free concentration exceeded the minimum inhibitory concentration (MIC) at a steady state (50%fT_>MIC, 100%fT_>MIC, and 100%fT_>4×MIC) for various combinations of dosage regimens and renal function was explored using Monte Carlo simulation.

Results

Twenty-one patients were prospectively enrolled in this

SUBMITTER: Seo H 

PROVIDER: S-EPMC10079447 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature