Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial.

ABSTRACT:

Background

Whole sporozoite immunization under chemoprophylaxis (CPS regime) induces long-lasting sterile homologous protection in the controlled human malaria infection model using Plasmodium falciparum strain NF54. The relative proficiency of liver-stage parasite development may be an important factor determining immunization efficacy. Previous studies show that Plasmodium falciparum strain NF135 produces relatively high numbers of large liver-stage schizonts in vitro. Here, we evaluate this strain for use in CPS immunization regimes.

Methods

In a partially randomized, open-label study conducted at the Radboudumc, Nijmegen, the Netherlands, healthy, malaria-naïve adults were immunized by three rounds of fifteen or five NF135-infected mosquito bites under mefloquine prophyl

SUBMITTER: van der Boor SC 

PROVIDER: S-EPMC10079489 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature