Relationships Between High-Resolution Computed Tomographic Features and Lung Function Trajectory in Patients With Asthma.

ABSTRACT:

Purpose

A subset of asthmatics suffers from persistent airflow limitation, known as remodeled asthma, despite optimal treatment. Typical quantitative scoring methods to evaluate structural changes of airway remodeling on high-resolution computed tomography (HRCT) are time-consuming and laborious. Thus, easier and simpler methods are required in clinical practice. We evaluated the clinical usefulness of a simple, semi-quantitative method based on 8 HRCT parameters by comparing asthmatics with a persistent decline of post-bronchodilator (BD)-FEV1 to those with a BD-FEV1 that normalized over time and evaluated the relationships of the parameters with BD-FEV1.

Methods

Asthmatics (n = 59) were grouped into 5 trajectories (Trs) according to the changes of BD-FEV1 over 1 year. Afte

SUBMITTER: Kim JH 

PROVIDER: S-EPMC10079522 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature