Cardiovascular Risk and Diseases in Patients With and Without Leptin-Melanocortin Pathway Variants.

ABSTRACT:

Objective

To study differences in cardiovascular risk factors and diseases between patients with and without genetic variants in the leptin-melanocortin pathway.

Methods

A cross-sectional study of patients with a history of severe obesity genotyped in June 2019 as participants of the Mayo Clinic Biobank was conducted in March 2022 to assess differences in cardiovascular risk and diseases between carriers of a heterozygous variant in the leptin-melanocortin pathway and noncarriers. Cardiovascular risk factors included hypertension, diabetes, dyslipidemia, and smoking. Cardiovascular disease includes coronary artery disease, peripheral artery disease, and cerebrovascular accidents. Patients with a history of bariatric surgery were excluded. We used logistic regression models t

SUBMITTER: Cifuentes L 

PROVIDER: S-EPMC10079551 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature