Non-esterified fatty acids and risk of peripheral artery disease in older adults: The cardiovascular health study.

ABSTRACT:

Background and aims

Non-esterified fatty acids have been implicated in the pathogenesis of diabetes and cardiovascular disease. No longitudinal study has assessed their effects on peripheral artery disease (PAD). We determined the relationships between NEFAs and incident clinical PAD and abnormal ankle-brachial index (ABI) in a population-based cohort of older persons.

Methods

We evaluated 4575 community living participants aged >65 years who underwent measurement of circulating NEFAs in fasting specimens and ABI in 1992-1993. Participants were assessed annually for clinical PAD until 2015 and underwent repeat ABI in 1998-1999. We used Cox proportional hazards regression to model the associations between NEFAs and risk of clinical PAD and logistic regression to model the ass

SUBMITTER: Ahiawodzi P 

PROVIDER: S-EPMC10079601 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature