Fate mapping RNA-sequencing reveal Malat1 regulates Sca1⁺ progenitor cells to vascular smooth muscle cells transition in vascular remodeling.

ABSTRACT: Regeneration of smooth muscle cells (SMCs) is vital in vascular remodeling. Sca1⁺ stem/progenitor cells (SPCs) can generate de novo smooth muscle cells after severe vascular injury during vessel repair and regeneration. However, the underlying mechanisms have not been conclusively determined. Here, we reported that lncRNA Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) was down-regulated in various vascular diseases including arteriovenous fistula, artery injury and atherosclerosis. Using genetic lineage tracing mice and veingraft mice surgery model, we found that suppression of lncRNA Malat1 promoted Sca1⁺ cells to differentiate into SMCs in vivo, resulting in excess SMC accumulation in neointima and vessel stenosis. Genetic ablation of Sca1⁺

SUBMITTER: Lyu L 

PROVIDER: S-EPMC10079726 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature