Investigation of oncolytic effect of recombinant Newcastle disease virus in primary and metastatic oral melanoma.

ABSTRACT: Malignant melanoma is aggressive cancer with a high rate of local invasiveness and metastasis. Currently, the treatment options for patients with advanced-stage and metastatic oral melanoma are limited. A promising treatment option is oncolytic viral therapy. This study aimed to evaluate novel therapies for malignant melanoma using a canine model. Oral melanoma, which frequently occurs in dogs is used as a model for human melanoma, was isolated and cultured and used for the evaluation of the tumor lytic effect induced by viral infection. We constructed a recombinant Newcastle disease virus (rNDV) that promotes the extracellular release of IFNγ from the virus-infected melanoma. The expression of oncolytic and apoptosis-related genes, the immune response by lymphocytes, and IFNγ expression w

SUBMITTER: Numpadit S 

PROVIDER: S-EPMC10079733 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature