Agreement in cerebrovascular reactivity assessed with diffuse correlation spectroscopy across experimental paradigms improves with short separation regression.

ABSTRACT:

Significance

Cerebrovascular reactivity (CVR), i.e., the ability of cerebral vasculature to dilate or constrict in response to vasoactive stimuli, is a biomarker of vascular health. Exogenous administration of inhaled carbon dioxide, i.e., hypercapnia (HC), remains the "gold-standard" intervention to assess CVR. More tolerable paradigms that enable CVR quantification when HC is difficult/contraindicated have been proposed. However, because these paradigms feature mechanistic differences in action, an assessment of agreement of these more tolerable paradigms to HC is needed.

Aim

We aim to determine the agreement of CVR assessed during HC, breath-hold (BH), and resting state (RS) paradigms.

Approach

Healthy adults were subject to HC, BH, and RS paradigms. End tidal carb

SUBMITTER: Cowdrick KR 

PROVIDER: S-EPMC10079775 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature