Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells.

ABSTRACT:

Background

Studies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a region commonly deleted in cancers, are associated with poor clinical outcome in the childhood cancer neuroblastoma. We have previously identified miR-323a-3p from this region to be downregulated in chemotherapy treated neuroblastoma cells compared to pre-treatment cells from the same patients. Furthermore, in neuroblastoma tumors, this miRNA is downregulated in advanced stage 4 disease compared to stage 1-2. In this study, we attempt to delineate the unknown functional roles of miR-323a-3p in neuroblastoma.

Methods

Synthetic miRNA mimics were used to overexpress <

SUBMITTER: Bhavsar SP 

PROVIDER: S-EPMC10079869 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature