A novel zinc metabolism-related gene signature to predict prognosis and immunotherapy response in lung adenocarcinoma.

ABSTRACT:

Background

Zinc is a key mineral element in regulating cell growth, development, and immune system. We constructed the zinc metabolism-related gene signature to predict prognosis and immunotherapy response for lung adenocarcinoma (LUAD).

Methods

Zinc metabolism-associated gene sets were obtained from Molecular Signature Database. Then, the zinc metabolism-related gene signature (ZMRGS) was constructed and validated. After combining with clinical characteristics, the nomogram for practical application was constructed. The differences in biological pathways, immune molecules, and tumor microenvironment (TME) between the different groups were analyzed. Tumor Immune Dysfunction and Exclusion algorithm (TIDE) and two immunotherapy datasets were used to evaluate the immunotherapy

SUBMITTER: Chang W 

PROVIDER: S-EPMC10079938 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature