Use of phage display biopanning as a tool to design CAR-T cells against glioma stem cells.

ABSTRACT:

Background

Glioblastoma (GBM) is both the most common and aggressive type of primary brain tumor, associated with high mortality rates and resistance to conventional therapy. Despite recent advancements in knowledge and molecular profiling, recurrence of GBM is nearly inevitable. This recurrence has been attributed to the presence of glioma stem cells (GSCs), a small fraction of cells resistant to standard-of-care treatments and capable of self-renewal and tumor initiation. Therefore, targeting these cancer stem cells will allow for the development of more effective therapeutic strategies against GBM. We have previously identified several 7-amino acid length peptides which specifically target GSCs through in vitro and in vivo phage display biopanning.

Methods and r

SUBMITTER: Potez M 

PROVIDER: S-EPMC10080078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature