Allergic sensitisation and type-2 inflammation is associated with new-onset and persistent allergic disease.

ABSTRACT:

Background

Allergic disease is common. The aim of this study was to look at the change in asthma and rhinitis over time and to characterise factors contributing to remission and persistence of disease.

Methods

This cohort study included 255 individuals with or without asthma and or rhinitis that participated in a population survey and a follow-up 10 years later. The participants were tested for allergic sensitisation, total IgE, multiplex allergen component analysis and type-2 inflammatory markers: exhaled nitric oxide (F_E NO), eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN).

Results

Of the 132 healthy individuals, 112 remained healthy, 16 developed rhinitis, 4 asthma and rhinitis over the 10 years. Out of 82 subjects with rhinitis

SUBMITTER: Blondal V 

PROVIDER: S-EPMC10080081 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature